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Related Concept Videos

Epilepsy and Seizures: Overview01:24

Epilepsy and Seizures: Overview

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Epilepsy is a chronic neurological disease marked by recurrent, unpredictable seizures. These seizures are caused by abnormal electrical discharges in the brain, leading to behavior, sensation, or consciousness alterations. They can also cause transient impairment of awareness, interfering with daily activities.
Various factors can trigger epilepsy, including genetic factors, brain damage, metabolic causes, and unknown etiology. Diagnosis of epilepsy involves electroencephalography (EEG), which...
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Seizures: Classification01:13

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Epilepsy is primarily characterized by unpredictable seizures, either provoked by an identifiable factor, such as injury or illness, or unprovoked, occurring spontaneously without apparent cause.
Seizures are typically classified into two main categories: focal and generalized seizures.
Focal Seizures
Focal seizures originate from specific regions of the brain. These seizures are further sub-classified into two types:
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Antiepileptic Drugs: Glutamate Antagonists01:14

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Glutamate is a fundamental neurotransmitter in the central nervous system, playing a vital role in neuronal communication and various cognitive processes. Glutamate stands as the principal excitatory neurotransmitter in the brain. Its presence is crucial for the communication between neurons, underpinning essential processes such as synaptic transmission, neuronal excitability, and plasticity. These functions are vital for higher-order cognitive processes, including learning and memory. The...
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Antiepileptic Drugs: GABAergic Pathway Potentiators01:18

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γ-aminobutyric acid or GABA, plays a pivotal role as an inhibitory neurotransmitter in the brain. GABA pathway potentiators, also known as GABAergic drugs, are a class of pharmaceutical agents designed to enhance the functioning of the GABAergic system. These medications primarily treat epilepsy, a neurological disorder characterized by recurrent seizures.
The key GABA pathway potentiators used in epilepsy management are as follows.
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Antiepileptic Drugs: Potassium Channel Activators01:20

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Ezocgabine or retigabine, an antiepileptic drug of remarkable efficacy, has revolutionized the management of seizures. It is a potassium channel activator, explicitly targeting the family of Q subtype potassium channels. It enhances the transmembrane potassium currents, regulating neuronal excitability. This action stabilizes the resting membrane potential, a pivotal factor in mitigating the hyperexcitability that characterizes epilepsy.
Ezogabine has gained approval as an adjunctive treatment...
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Antiepileptic Drugs: Modulators of Neurotransmitter Release Mediated by SV2A Protein01:20

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Antiepileptic drugs, such as levetiracetam (Keppra) and brivaracetam (Briviact), have emerged as crucial tools in managing epilepsy. These medications exert their therapeutic effects by targeting the synaptic vesicle protein SV2A, a transmembrane glycoprotein primarily found in the brain.
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Updated: Apr 13, 2026

Resting-State Connectivity and Neuroimaging of Prefrontal Cortex Activity During a Block-Design Yoga Asana Practice Using fNIRS
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Yoga for epilepsy.

Mariangela Panebianco1, Kalpana Sridharan, Sridharan Ramaratnam

  • 1Department of Molecular and Clinical Pharmacology, Institute of Translational Medicine, University of Liverpool, Clinical Sciences Centre for Research and Education, Lower Lane, Liverpool, UK, L9 7LJ.

The Cochrane Database of Systematic Reviews
|May 3, 2015
PubMed
Summary
This summary is machine-generated.

Yoga may help control seizures in epilepsy patients, showing potential benefits over no treatment. However, limited studies and methodological issues prevent firm conclusions on yoga

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Area of Science:

  • Neurology
  • Complementary Medicine

Background:

  • Yoga may influence electroencephalogram and autonomic nervous system, potentially controlling seizures.
  • Yoga is explored as a therapeutic option for epilepsy due to its relaxation and stress-reduction properties.

Purpose of the Study:

  • To assess yoga's efficacy in achieving seizure freedom in epilepsy patients.
  • To evaluate yoga's impact on seizure frequency and duration.
  • To determine if yoga improves quality of life for individuals with epilepsy.

Main Methods:

  • Systematic review and meta-analysis of randomized controlled trials (RCTs).
  • Searched multiple databases including Cochrane, MEDLINE, and SCOPUS up to March 2015.
  • Included adults with uncontrolled epilepsy comparing yoga to no treatment or other behavioral interventions.

Main Results:

  • Two unblinded trials with 50 participants were analyzed.
  • Yoga showed a potential benefit in reducing seizure frequency and duration compared to no treatment or sham yoga.
  • No significant difference was found between yoga and Acceptance and Commitment Therapy (ACT); quality of life data was limited.

Conclusions:

  • Preliminary findings suggest yoga may have a beneficial effect on seizure control in epilepsy.
  • Methodological limitations including small sample sizes and lack of blinding restrict definitive conclusions.
  • Further high-quality research is necessary to establish yoga's efficacy for refractory epilepsy.