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Updated: Apr 13, 2026

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Published on: February 13, 2021
High left ventricular outflow tract gradient: Aortic stenosis, obstructive hypertrophic cardiomyopathy or both?
Inês Almeida1, Francisca Caetano1, Joana Trigo1
1Serviço de Cardiologia, Centro Hospitalar e Universitário de Coimbra - Hospital Geral, Coimbra, Portugal.
This case study highlights the diagnostic challenges of co-existing hypertrophic cardiomyopathy and severe aortic stenosis. Successful surgical aortic valve replacement was achieved after identifying a high left ventricular outflow tract gradient.
Area of Science:
- Cardiology
- Cardiovascular Imaging
Background:
- Hypertrophic cardiomyopathy and aortic stenosis are distinct cardiovascular conditions.
- Co-occurrence of these two conditions presents unique clinical scenarios.
Observation:
- A patient with clinical deterioration was investigated for complex cardiac symptoms.
- High-fidelity imaging, particularly transesophageal echocardiography, was crucial for diagnosis.
- A significant left ventricular outflow tract gradient was identified.
Findings:
- The patient was diagnosed with severe aortic stenosis co-existing with hypertrophic cardiomyopathy.
- Accurate diagnosis was challenging due to overlapping clinical presentations.
Implications:
- This case underscores the importance of advanced imaging in diagnosing complex cardiovascular diseases.
- Management strategies for patients with combined hypertrophic cardiomyopathy and aortic stenosis require careful consideration.
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