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Hypertriglyceridemia in an outpatient department--Significance as an atherosclerotic risk factor

M Scholz1, S Tselmin1, S Fischer1

  • 1Department of Internal Medicine III, University Hospital Carl Gustav Carus at the Technische Universität Dresden, Fetscherstr. 74, 01307 Dresden, Germany.

Atherosclerosis. Supplements
|May 5, 2015
PubMed

Insights

Elevated triglycerides (hypertriglyceridemia) increase cardiovascular event risk, especially with metabolic vascular syndrome. Lipid-lowering therapy effectively reduced cardiovascular events and pancreatitis incidence in patients.

Area of Science:

  • Cardiology
  • Endocrinology
  • Pharmacology

Background:

  • The link between high triglycerides (HTG) and cardiovascular diseases (CVD) is debated.
  • This study examines cardiovascular events (CVE) and pancreatitis in HTG patients.

Purpose of the Study:

  • To analyze CVE and pancreatitis incidence in HTG patients.
  • To evaluate therapeutic regimens for HTG.
  • To assess the impact of HTG severity and co-existing metabolic vascular syndrome (MVS) on outcomes.

Main Methods:

  • Retrospective analysis of 232 HTG patients (183 mild, 49 severe).
  • Subgroup analysis by gender, MVS presence, and lipid levels.
  • Evaluation of therapeutic interventions, including omega-3 fatty acids and fibrates.

Main Results:

  • CVE occurred at a younger age compared to general population rates.
  • TG levels, CVE, and pancreatitis rates decreased with therapy.
  • Non-compliant patients with persistent severe HTG faced high pancreatitis risk.

Conclusions:

  • No direct TG-CVE link found, but HTG combined with MVS is highly dangerous.
  • Lipid-lowering therapy effectively reduced CVE and pancreatitis.
  • Patient compliance is crucial for managing severe HTG and preventing complications.
Abstract

Keywords:
AtherosclerosisCardiovascular riskHypertriglyceridemiaPancreatitisTriglycerides

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