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Bronchial asthma and hypovitaminosis D in Saudi children

Huria M Aldubi1, Eman M Alissa1, Hayat Z Kamfar2

  • 1Department of Clinical Biochemistry, King AbdulAziz University, Jeddah 21483, Saudi Arabia.

Asia Pacific Allergy
|May 5, 2015
PubMed

Insights

Low vitamin D levels are common in children with asthma and linked to increased allergy and asthma severity markers. This suggests vitamin D deficiency may worsen childhood asthma.

Area of Science:

  • Pediatric Allergy and Immunology
  • Nutritional Immunology
  • Respiratory Medicine

Background:

  • Asthma is a prevalent childhood respiratory condition triggered by immune overreactions to environmental factors.
  • Vitamin D possesses known immunomodulatory effects, making it a potential factor in asthma development and severity.

Purpose of the Study:

  • To examine the association between vitamin D status and indicators of asthma severity in Saudi children.
  • To investigate correlations between vitamin D levels and various immunological and inflammatory markers related to asthma.

Main Methods:

  • A study involving 70 Saudi children (with and without asthma) in Jeddah.
  • Assessment of asthma control using the Childhood Asthma Control Test, pulmonary function tests (peak expiratory flow), and anthropometric measurements.
  • Analysis of blood samples for vitamin D (25-hydroxyvitamin D), bone profile, cytokine profiles (IL-10, TNF-α, PDGF), IgE, and eosinophil counts.

Main Results:

  • High prevalence of vitamin D deficiency (hypovitaminosis D) observed in asthmatic children.
  • Significantly elevated markers of allergy and asthma severity were noted in children with vitamin D deficiency compared to controls.
  • Lower 25-hydroxyvitamin D levels correlated with increased asthma prevalence and severity markers.

Conclusions:

  • Hypovitaminosis D is widespread in the studied population, particularly among children with asthma.
  • Vitamin D deficiency is associated with increased allergy markers and asthma severity in children.
  • The findings highlight a significant link between low vitamin D levels and childhood asthma.
Abstract

Keywords:
AsthmaChildHypersensitivitySaudi ArabiaVitamin D

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