Investigating the function of deep cortical and subcortical structures using stereotactic electroencephalography:
Robert A McGovern1, Tarini Ratneswaren2, Elliot H Smith3
1Department of Neurosurgery, Columbia University Medical Center, New York Presbyterian Hospital; Columbia University Medical Center, New York Presbyterian Hospital; ram2140@columbia.edu.
Journal of Visualized Experiments : Jove
|May 5, 2015
Summary
Stereotactic Electroencephalography (SEEG) enables brain function research by recording local field potentials (LFPs). This study explores the dorsal anterior cingulate cortex (dACC) role in cognitive control using SEEG.
Area of Science:
- Neuroscience
- Neurosurgery
- Cognitive Science
Background:
- Medically intractable epilepsy requires precise seizure focus localization.
- Stereotactic Electroencephalography (SEEG) offers deep brain access for epilepsy surgery planning.
- SEEG provides a unique window into brain function beyond seizure localization.
Purpose of the Study:
- To demonstrate the utility of SEEG for investigating cognitive processes.
- To explore the role of the dorsal anterior cingulate cortex (dACC) in cognitive control.
- To detail the methodology for SEEG recording and analysis in cognitive tasks.
Main Methods:
- Detailed description of the SEEG procedure and chronic electrode placement.
- Recording of local field potential (LFP) data from consenting subjects during a cognitive task.
- Analysis of SEEG signals from the dACC during a cognitive interference task.
Main Results:
- Demonstration of SEEG's capability to record neural activity from deep brain regions like the dACC.
- Successful application of SEEG to investigate the dACC's involvement in cognitive control.
- Methodology for signal acquisition and analysis in SEEG-based cognitive neuroscience.
Conclusions:
- SEEG is a valuable tool for studying human cognitive processes.
- The dACC plays a significant role in cognitive control, as evidenced by SEEG data.
- Further applications of SEEG in cognitive neuroscience are suggested.
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