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Physiological functions of vitamin D: what we have learned from global and conditional VDR knockout mouse studies
Tatsuo Suda1, Ritsuko Masuyama2, Roger Bouillon3
1Research Center for Genomic Medicine, Saitama Medical University, Saitama, Japan.
Abstract:
The physiological role of vitamin D depends on calcium supply and calcium balance. When the calcium balance is normal, the major target of vitamin D is intestine. Vitamin D stimulates mainly active intestinal calcium transport mechanism. During a negative calcium balance, bone effects of vitamin D become dominant. Thus, the role of vitamin D in maintaining normocalcemia appears to have priority over skeletal integrity in these situations.
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