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Related Concept Videos

Hepatitis01:25

Hepatitis

59
Hepatitis is an inflammatory condition of the liver most commonly caused by hepatotropic viruses (A–E), though non-infectious causes such as alcohol and drugs also exist.Hepatitis AHepatitis A virus (HAV) is a non-enveloped RNA virus of the Picornaviridae family. It is primarily transmitted via the fecal-oral route, typically through ingestion of contaminated food or water. After ingestion, HAV enters the bloodstream through the oropharynx or intestinal epithelium and reaches the liver.
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Autoimmune Disorders01:29

Autoimmune Disorders

2.3K
Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune...
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Gastritis-II: Pathophysiology01:17

Gastritis-II: Pathophysiology

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Gastritis is marked by disruption of the mucosal barrier that usually protects the stomach tissue from digestive juices and manifests in acute and chronic forms.
In acute gastritis, the gastric mucosa becomes swollen and red and undergoes superficial erosion. Superficial ulceration may lead to bleeding.
In chronic gastritis, persistent or repeated insults lead to chronic inflammatory changes and, eventually, thinning or atrophy of the gastric tissue.
Gastritis can stem from various causes, each...
1.8K
Chronic Pancreatitis I: Introduction01:24

Chronic Pancreatitis I: Introduction

924
The pancreas, an elongated and flat gland situated behind the stomach, serves a vital function in digesting food and managing blood sugar levels.
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
924
Myasthenia Gravis: Overview and Treatment01:20

Myasthenia Gravis: Overview and Treatment

3.6K
Myasthenia gravis is a neuromuscular transmission disorder characterized by weakness and increased fatigability of skeletal muscles. It is an autoimmune disease affecting approximately one in 2000 people, where antibodies against the α1 subunit of nicotinic acetylcholine receptors are produced.
These antibodies interfere with the function of the nicotinic receptors in three ways: by binding to the receptor and disrupting acetylcholine binding; by causing cross-linking of receptors which...
3.6K
Gastritis-I: Introduction and Types01:27

Gastritis-I: Introduction and Types

3.5K
Gastritis, defined by the inflammation or irritation of the stomach lining or gastric mucosa, manifests in several distinct forms: acute, chronic, reactive, and a specific subtype known as autoimmune metaplastic atrophic gastritis.
Acute gastritis presents as a sudden inflammation triggered by various stressors to the stomach lining, such as exposure to corrosive agents, local irritants like aspirin and other NSAIDs, alcohol consumption, radiation therapy, physical trauma, severe burns, sepsis,...
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Related Experiment Video

Updated: Apr 13, 2026

The CYP2D6 Animal Model: How to Induce Autoimmune Hepatitis in Mice
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[Autoimmune hepatitis].

Armand Garioud, Jean-François Cadranel

    La Revue Du Praticien
    |May 6, 2015
    PubMed
    Summary
    This summary is machine-generated.

    Autoimmune hepatitis is a rare chronic liver disease caused by an immune response against hepatocytes. Treatment involves corticosteroids and immunosuppressants, with careful monitoring for drug withdrawal.

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    Area of Science:

    • Hepatology
    • Immunology
    • Internal Medicine

    Context:

    • Autoimmune hepatitis (AIH) is a chronic liver condition.
    • It involves immune-mediated damage to liver cells (hepatocytes).
    • The exact cause of AIH remains unknown.

    Purpose:

    • To summarize the key aspects of autoimmune hepatitis.
    • To outline diagnostic criteria and treatment strategies for AIH.
    • To provide an overview of current management approaches.

    Summary:

    • AIH presents with portal tract necroinflammation due to an immune response against hepatocytes.
    • Diagnosis relies on clinical, biochemical, immunological, and histological findings.
    • Treatment typically combines predniso(lo)ne and azathioprine, with budesonide as an alternative.

    Impact:

    • Provides a concise overview of autoimmune hepatitis for clinicians and researchers.
    • Highlights the importance of a multi-faceted diagnostic approach.
    • Emphasizes the standard treatment protocols and criteria for drug withdrawal.