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Enhanced epidermal localization of topically applied steroids using SPACE™ peptide
Sunny Kumar1, Ming Chen, Aaron C Anselmo
1Center for Bioengineering, Department of Chemical Engineering, University of California, Santa Barbara, CA, 93106, USA.
Drug Delivery and Translational Research
|May 6, 2015
Summary
SPACE™ peptide enhances topical corticosteroid (TCs) skin penetration and retention. This peptide improves TCs
Area of Science:
- Dermatology
- Pharmaceutics
- Biochemistry
Background:
- Topical corticosteroids (TCs) efficacy and safety rely on skin penetration and retention.
- Optimizing TCs' epidermal delivery is crucial for therapeutic outcomes.
Purpose of the Study:
- To evaluate SPACE™ peptide's ability to enhance epidermal delivery and localization of model topical corticosteroids.
Main Methods:
- In vitro and in vivo skin penetration studies using corticosterone, hydrocortisone, and triamcinolone acetonide.
- Formulations included SPACE™ peptide in various concentrations.
- Mass spectrometry was used to analyze peptide-drug interactions.
- Efficacy/safety ratio was assessed by comparing skin deposition to receiver concentrations.
Main Results:
- SPACE™ peptide formulations significantly enhanced epidermal penetration and localization of corticosterone.
- SPACE™ peptide formulations showed higher drug deposition ratios (efficacy/safety) compared to controls.
- Mass spectrometry confirmed SPACE™ peptide association with corticosterone, suggesting a retention mechanism.
- Enhanced dermal retention of hydrocortisone and triamcinolone acetonide was observed.
- In vivo mouse studies confirmed enhanced hydrocortisone skin retention without increased systemic levels.
Conclusions:
- SPACE™ peptide effectively enhances the epidermal delivery and dermal localization of topical corticosteroids.
- This peptide improves the efficacy/safety profile of topical steroids by increasing local retention.
- SPACE™ peptide represents a promising formulation additive for topical steroid delivery.
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