Timing of Mean Transit Time Maximization is Associated with Neurological Outcome After Subarachnoid Hemorrhage

Computed tomography perfusion (CTP) has gained significant relevance for the radiological screening of patients at risk of developing delayed cerebral ischemia (DCI) after aneurysmal subarachnoid hemorrhage (aSAH). Particularly, the impact of MTT_PEAK, i.e., the maximal mean transit time value in a series of CTP measurements, for the prediction of long-term outcome has recently been demonstrated by our group. Complementing this recent work, the present study investigated how the timing of MTT_PEAK affected the long-term outcome after aneurysmal subarachnoid hemorrhage.

CTP examinations from 103 patients with clinical deterioration attributed to DCI after aSAH were retrospectively analyzed for time interval between SAH ictus and onset of MTT_PEAK in association with modified Rankin Scale (mRS) 23.1 months after SAH.

Patients with unfavorable outcome (mRS > = 2) suffered significant earlier MTT_PEAK onsets than patients with favorable outcome (mRS = 0 and 1). MTT_PEAK within the first week was associated with significantly higher mRS scores compared to later MTT_PEAK. Timing of MTT_PEAK together with the value of MTT_PEAK and initial World Federation of Neurosurgical Societies (WFNS) grade was a significant predictor for an unfavorable outcome (mRS > = 2).

The current findings suggest a presumably higher vulnerability of the brain to early microcirculatory impairments after aSAH and highlight that timing of MTT elevations could be considered for the identification of patients at increased risk for poor neurological outcome due to DCI.