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Related Experiment Video

Updated: Apr 13, 2026

Analysis of Gene Expression Changes in the Rat Hippocampus After Deep Brain Stimulation of the Anterior Thalamic Nucleus
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Nucleus accumbens stimulation in partial epilepsy--a randomized controlled case series.

Alexander B Kowski1, Jürgen Voges2,3, Hans-Jochen Heinze3,4

  • 1Department of Neurology, Epilepsy-Center Berlin-Brandenburg, Charité - Universitätsmedizin Berlin, Germany.

Epilepsia
|May 6, 2015
PubMed
Summary

Deep brain stimulation of the nucleus accumbens shows promise for treating difficult epilepsy. Three of four patients experienced over 50% fewer seizures with this neuromodulative approach.

Keywords:
Anterior thalamic nucleusDeep brain stimulationEpilepsyNucleus accumbensSeizures

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Area of Science:

  • Neurology
  • Neurosurgery
  • Epileptology

Background:

  • Neuromodulative treatments are crucial for drug-resistant epilepsy.
  • Controlled data on deep brain stimulation (DBS) is limited, primarily focusing on centromedian and anterior thalamic nuclei.

Purpose of the Study:

  • To evaluate the efficacy and safety of nucleus accumbens stimulation in patients with intractable partial epilepsy.
  • To explore the potential benefits of concomitant anterior thalamic nucleus stimulation in non-responders.

Main Methods:

  • A randomized controlled cross-over study involving four patients with intractable partial epilepsy.
  • Assessment included seizure frequency, neurocognitive tests, and validated quality of life and depression inventories.
  • An open-label phase investigated additional anterior thalamic nucleus stimulation for non-responders.

Main Results:

  • Nucleus accumbens stimulation resulted in a ≥ 50% reduction in disabling seizure frequency in three of four patients.
  • No significant changes were observed in patient-reported outcomes or neurocognitive testing.
  • Concomitant anterior thalamic nucleus stimulation did not provide further improvement in responders.

Conclusions:

  • Nucleus accumbens stimulation appears safe and effective for intractable partial epilepsy.
  • Further validation through a large-scale multicenter study is warranted to confirm these findings.