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Chimeric antigen receptor T cells are vulnerable to immunosuppressive mechanisms present within the tumor

Gregory L Beatty1, Edmund K Moon2

  • 1Abramson Cancer Center; Department of Medicine; Division of Hematology-Oncology; University of Pennsylvania Perelman School of Medicine ; Philadelphia, PA USA.

Oncoimmunology
|May 6, 2015
PubMed

Keywords:
CAR, chimeric antigen receptorLag3, lymphocyte-activation gene 3PD1, programmed cell death 1PDL1, programmed death ligand 1TIM3, T cell immunoglobulin domain and mucin domain 3adoptive cell therapycancerchimeric antigen receptor T cellsimmune checkpoint moleculestumor microenvironment

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