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Updated: Apr 13, 2026

In Vitro Assay to Study Tumor-macrophage Interaction
Published on: August 1, 2019
Targeting tumor-associated macrophages in cancer therapy and understanding their complexity
Michael A Cannarile1, Carola H Ries1, Sabine Hoves1
1Roche Pharmaceutical Research and Early Development; Discovery Oncology ; Roche Innovation Center Penzberg ; Penzberg, Germany.
Abstract:
Macrophage infiltration has been identified as an independent, poor prognostic factor for patients afflicted with various cancer entities. However, the characterization of tumor-associated macrophages (TAMs) prior to and following cancer patient treatment has been limited. Our study analyzed tumor biopsies before and after anti-CSF-1R antibody treatment unraveling the nature of TAMs and providing novel insights into their phenotypic and functional characteristics in cancer.
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