Related Experiment Video
Updated: Apr 13, 2026

07:35
A Portal Vein Injection Model to Study Liver Metastasis of Breast Cancer
Published on: December 26, 2016
43.4K
Lessons from immunology: IL4R directly promotes mammary tumor metastasis
Katherine T Venmar1, Barbara Fingleton1
1Department of Cancer Biology; Vanderbilt University School of Medicine ; Nashville, TN USA.
Oncoimmunology
|May 6, 2015
Abstract:
Interleukin-4 (IL4), a Th2 cytokine, signals through IL4 receptors (IL4Rs) to regulate increased lymphocyte proliferation and survival. We have recently discovered that IL4 also promotes these phenotypes in mammary cancer cells expressing IL4Rs to enhance their metastatic ability. Targeting IL4/IL4R signaling on cancer cells themselves may limit metastatic disease.

