Incidence trends for childhood type 1 diabetes in India

Kanakatte Mylariah Prasanna Kumar1

  • 1Consultant Endocrinologist, Centre for Diabetes and Endocrine Care, Bangalore Diabetes hospital, Bengaluru, Karnataka, India.

Insights

Type 1 diabetes mellitus (T1DM) affects an estimated 97,700 children in India. Studies reveal T1DM is more prevalent in India than in many Asian countries, with varying rates across regions.

Area of Science:

  • Pediatrics
  • Endocrinology
  • Public Health

Background:

  • Type 1 diabetes mellitus (T1DM) is a significant health concern in children.
  • Estimates suggest a substantial number of children in India live with T1DM.
  • Previous studies indicated T1DM prevalence in specific Indian regions.

Purpose of the Study:

  • To estimate the prevalence and incidence of T1DM in children across various regions of India.
  • To compare T1DM rates in India with other Asian countries.
  • To identify regional variations in T1DM diagnosis and prevalence.

Main Methods:

  • Analysis of data from a 1992 population-based study in South India.
  • Review of the Karnataka state T1DM registry data over 13 years.
  • Examination of prevalence data from Karnal, Haryana, distinguishing urban and rural areas.

Main Results:

  • The first South India study reported a prevalence of 0.26/1000 children, with a peak diagnosis age of 12 years.
  • Karnataka's T1DM registry showed incidence rates of 3.7-4.0/100,000 children.
  • Karnal district reported an average T1DM prevalence of 10.20/100,000, with urban areas at 26.6/100,000.

Conclusions:

  • Insulin-dependent diabetes (T1DM) is not rare in Indian children and its prevalence is higher than in many Asian nations.
  • Significant regional variations in T1DM prevalence exist within India.
  • An estimated 18,000 new cases of T1DM in children under 15 were diagnosed in 2011 in the studied regions.

Related Concept Videos

Diabetes Mellitus: Overview and Type I Subtype01:22

Diabetes Mellitus: Overview and Type I Subtype

Diabetes mellitus is a chronic metabolic disorder characterized by high blood glucose levels due to inadequate insulin production, insulin resistance, or both. The condition affects millions worldwide and can significantly impact their health and quality of life.
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
6.3K
Diabetes Mellitus: Type 2 and Gestational01:22

Diabetes Mellitus: Type 2 and Gestational

Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
5.8K
Pathophysiology of Diabetes01:20

Pathophysiology of Diabetes

Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
4.5K
Diabetes: Symptoms, Diagnosis, and Complications01:15

Diabetes: Symptoms, Diagnosis, and Complications

For most patients, experiencing several weeks of polyuria, polydipsia, fatigue, and significant weight loss may indicate the presence of diabetes. Furthermore, adults displaying the phenotypic appearance of type 2 diabetes (particularly those who are obese and not initially insulin-requiring), may have islet cell autoantibodies, suggesting autoimmune-mediated β cell destruction and a diagnosis of latent autoimmune diabetes of adults (LADA). The categorization of glucose homeostasis is...
2.9K
Prevalence and Incidence01:08

Prevalence and Incidence

In statistical epidemiology and health sciences, two essential metrics—prevalence and incidence—are fundamental for understanding disease dynamics within a population. These measures enable public health officials, epidemiologists, and researchers to assess the burden of diseases, allocate resources effectively, and design impactful public health policies and interventions.
Prevalence indicates the proportion of individuals in a population who have a specific disease or health...
2.4K
Insulin: Dosing Regimen and Adverse Effects01:16

Insulin: Dosing Regimen and Adverse Effects

Insulin-replacement therapy usually includes both long-acting insulin (basal) and short-acting insulin (to cater to postprandial needs). In a diverse group of type 1 diabetes patients, the average daily insulin dose is typically 0.5-0.7 units/kg body weight. However, obese patients and pubertal adolescents may need more due to insulin resistance.
The basal dose constitutes about 40%-50% of the total daily dose, with the rest as premeal insulin. The mealtime insulin dose should mirror...
1.3K