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Published on: January 7, 2016
Challenges in the Diagnosis and Management of Growth Hormone Deficiency in India
Mathew John1, Ekaterina Koledova2, Kanakatte Mylariah Prasanna Kumar3
1Providence Endocrine and Diabetes Specialty Centre, Thiruvananthapuram, Kerala, India.
Insights
Growth hormone deficiency (GHD) affects many Indian children with short stature (SS). Addressing diagnostic and treatment challenges through education, improved monitoring, and accessible therapies is crucial for better outcomes.
Area of Science:
- Pediatric Endocrinology
- Growth Disorders
- Public Health
Background:
- Short stature (SS) affects approximately 150,000 children annually in India.
- Growth hormone deficiency (GHD) is a primary endocrine and treatable cause of SS.
- Limited data on GHD prevalence in India hinders problem magnitude estimation.
Conclusions:
- Overcoming GHD diagnostic and treatment hurdles is essential for affected children.
- Accessible and user-friendly GH therapy delivery systems can improve adherence.
- A multi-faceted approach involving education, training, and policy is needed to improve GHD care in India.
Abstract:
In clinical practice, every year approximately 150,000 children are referred with short stature (SS) based on a cut-off of fifth percentile. The most important endocrine and treatable cause of SS is growth hormone deficiency (GHD). The lack of reliable data on the prevalence of GHD in India limits estimation of the magnitude of this problem. The diagnosis and treatment of GHD are hurdled with various challenges, restricting the availability of growth hormone (GH) therapy to only a very limited segment of the children in India. This review will firstly summarize the gaps and challenges in diagnosis and treatment of GHD based on literature analysis. Subsequently, it presents suggestions from the members at advisory board meetings to overcome these challenges. The advisory board suggested that early initiation of the therapy could better the chances of achieving final adult height within the normal range for the population. Education and awareness about growth disorders among parents, regular training for physicians, and more emphasis on using the Indian growth charts for growth monitoring would help improve the diagnosis and treatment of children with GHD. Availability of an easy-to-use therapy delivery system could also be beneficial in improving adherence and achieving satisfactory outcomes.
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