Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Proteomics01:33

Proteomics

10.2K
A proteome is the entire set of proteins that a cell type produces. We can study proteomes using the knowledge of genomes because genes code for mRNAs, and the mRNAs encode proteins. Although mRNA analysis is a step in the right direction, not all mRNAs are translated into proteins.
Proteomics is the study of proteomes' function. It involves the large-scale systematic study of the proteome to denote the protein complement expressed by a genome. Scientist Mark Wilkins coined the term...
10.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Challenges and future directions for multiple sclerosis after the 2024 McDonald diagnostic criteria.

Nature medicine·2026
Same author

Corrigendum to "A Pre-symptomatic phase of tumefactive multiple sclerosis mirrors radiologically isolated syndrome" [Multiple Sclerosis and Related Disorders 112 (2026) 107312].

Multiple sclerosis and related disorders·2026
Same author

The contribution of trapezius and sternocleidomastoideus motor evoked potentials in the diagnosis of Amyotrophic lateral sclerosis.

Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology·2026
Same author

Socioeconomic status in Behçet's syndrome.

Clinical and experimental rheumatology·2026
Same author

Efficacy and Safety of Patients With Relapsing Multiple Sclerosis Switching to Ocrelizumab Due to Suboptimal Treatment Response: Results of the 4-Year CASTING-LIBERTO Trial.

European journal of neurology·2026
Same author

A Pre-symptomatic phase of tumefactive multiple sclerosis mirrors radiologically isolated syndrome.

Multiple sclerosis and related disorders·2026

Related Experiment Video

Updated: Apr 13, 2026

A High Throughput, Multiplexed and Targeted Proteomic CSF Assay to Quantify Neurodegenerative Biomarkers and Apolipoprotein E Isoforms Status
07:08

A High Throughput, Multiplexed and Targeted Proteomic CSF Assay to Quantify Neurodegenerative Biomarkers and Apolipoprotein E Isoforms Status

Published on: October 20, 2016

8.5K

CSF Proteomics Identifies Specific and Shared Pathways for Multiple Sclerosis Clinical Subtypes.

Timucin Avsar1, İlknur Melis Durası2, Uğur Uygunoğlu3

  • 1Dr. Orhan Öcalgiray Molecular Biology-Biotechnology and Genetics Research Center, Istanbul Technical University, Istanbul, Turkey.

Plos One
|May 6, 2015
PubMed
Summary
This summary is machine-generated.

This study identifies distinct molecular pathways in multiple sclerosis (MS) subtypes using proteomics. Findings reveal shared and specific pathways, offering potential therapeutic targets for immune-mediated CNS diseases.

More Related Videos

A Streamlined Approach for Mass Spectrometry-Based Proteomics Using Selected Tissue Regions
09:00

A Streamlined Approach for Mass Spectrometry-Based Proteomics Using Selected Tissue Regions

Published on: April 18, 2025

1.6K
Sample Preparation for Endopeptidomic Analysis in Human Cerebrospinal Fluid
10:23

Sample Preparation for Endopeptidomic Analysis in Human Cerebrospinal Fluid

Published on: December 4, 2017

9.5K

Related Experiment Videos

Last Updated: Apr 13, 2026

A High Throughput, Multiplexed and Targeted Proteomic CSF Assay to Quantify Neurodegenerative Biomarkers and Apolipoprotein E Isoforms Status
07:08

A High Throughput, Multiplexed and Targeted Proteomic CSF Assay to Quantify Neurodegenerative Biomarkers and Apolipoprotein E Isoforms Status

Published on: October 20, 2016

8.5K
A Streamlined Approach for Mass Spectrometry-Based Proteomics Using Selected Tissue Regions
09:00

A Streamlined Approach for Mass Spectrometry-Based Proteomics Using Selected Tissue Regions

Published on: April 18, 2025

1.6K
Sample Preparation for Endopeptidomic Analysis in Human Cerebrospinal Fluid
10:23

Sample Preparation for Endopeptidomic Analysis in Human Cerebrospinal Fluid

Published on: December 4, 2017

9.5K

Area of Science:

  • Neuroimmunology
  • Proteomics
  • Bioinformatics

Background:

  • Multiple sclerosis (MS) is a heterogeneous immune-mediated disease of the central nervous system (CNS).
  • The molecular mechanisms driving MS phenotypic heterogeneity are not fully understood.
  • Understanding these mechanisms is crucial for developing targeted therapies.

Purpose of the Study:

  • To investigate molecular pathways in subclinical MS subtypes.
  • To identify differentially expressed proteins and associated biological pathways in cerebrospinal fluid.
  • To explore the etiopathogenesis of MS heterogeneity.

Main Methods:

  • Proteomic and bioinformatics analyses were performed on cerebrospinal fluid from 179 patients.
  • Patients included those with clinically isolated syndrome, relapsing-remitting MS, and progressive MS.
  • KEGG pathway analysis was conducted using the PANOGA tool.

Main Results:

  • 151 proteins were found to be differentially expressed across MS subtypes compared to controls.
  • Key pathways identified include aldosterone-regulated sodium reabsorption, renin-angiotensin system, notch signaling, and vitamin digestion/absorption.
  • Specific pathways were associated with immune cell migration, Th17 immunity, and remyelination.

Conclusions:

  • All MS clinical forms share common biological pathways.
  • Distinct, pathophysiology-related pathways are specific to MS subtypes.
  • These subtype-specific pathways may hold significant therapeutic implications for MS treatment.