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Updated: Apr 13, 2026
11:39
The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis
Published on: July 11, 2013
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Psoriasis patients' willingness to accept side-effect risks for improved treatment efficacy
Teresa L Kauf1, Jui-Chen Yang2, Alexa B Kimball3
1a Cubist Pharmaceuticals , Lexington , MA , USA .
The Journal of Dermatological Treatment
|May 7, 2015
Summary
Psoriasis patients accept significant health risks for symptom improvement. They are willing to tolerate higher risks of infection, tuberculosis, and lymphoma for clearer skin, indicating a strong desire for treatment efficacy.
Area of Science:
- Dermatology
- Public Health
- Health Economics
Background:
- Psoriasis treatment decisions often prioritize efficacy over side-effect risks.
- Previous studies overlooked potentially fatal risks associated with biologic treatments for psoriasis.
- Understanding patient risk tolerance is crucial for informed treatment choices.
Purpose of the Study:
- To quantify the acceptable risk levels patients with psoriasis are willing to endure for symptom improvement.
- To assess patient preferences regarding treatment efficacy versus severe adverse event risks.
Main Methods:
- A discrete-choice experiment was conducted with adult psoriasis patients recruited via the National Psoriasis Foundation.
- Patients evaluated hypothetical treatment scenarios defined by plaque severity, body surface area (BSA) involvement, and risks of tuberculosis, serious infection, and lymphoma.
- 1608 patients completed nine choice questions to determine risk-benefit trade-offs.
Main Results:
- For 25% BSA clearance with mild plaques, patients accepted a 20% risk of serious infection, 10% risk of tuberculosis, and 2% risk of lymphoma.
- For 25% BSA clearance with severe plaques, acceptable risks increased to 54% for serious infection, 36% for tuberculosis, and 8% for lymphoma.
- These acceptable risk levels often exceeded likely clinical exposures.
Conclusions:
- Psoriasis patients demonstrate a willingness to accept substantial health risks for improved symptom control.
- Risk tolerance varies among individuals, highlighting the need for personalized treatment discussions.
- Findings suggest that perceived efficacy strongly influences patient acceptance of treatment-associated risks.
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