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Updated: Apr 12, 2026

A Microfluidic System with Surface Patterning for Investigating Cavitation Bubble(s)–Cell Interaction and the Resultant Bioeffects at the Single-cell Level

A Microfluidic System with Surface Patterning for Investigating Cavitation Bubble(s)–Cell Interaction and the Resultant Bioeffects at the Single-cell Level

Published on: January 10, 2017

Microfluidic systems for cell pairing and fusion.

Burak Dura¹, Joel Voldman

¹Research Laboratory of Electronics, Massachusetts Institute of Technology (MIT), 50 Vassar Street, Cambridge, MA, 02139, USA.

Methods in Molecular Biology (Clifton, N.J.)

|May 8, 2015

Summary

This summary is machine-generated.

This study presents a microfluidics method for efficient cell pairing and fusion, improving hybrid generation yields. The technique offers controllable cell manipulation for diverse laboratory applications.

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Last Updated: Apr 12, 2026

A Microfluidic System with Surface Patterning for Investigating Cavitation Bubble(s)–Cell Interaction and the Resultant Bioeffects at the Single-cell Level

A Microfluidic System with Surface Patterning for Investigating Cavitation Bubble(s)–Cell Interaction and the Resultant Bioeffects at the Single-cell Level

Published on: January 10, 2017

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Establishing Single-Cell Based Co-Cultures in a Deterministic Manner with a Microfluidic Chip

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Published on: September 27, 2019

Area of Science:

Biotechnology
Cell Biology
Microfluidics

Background:

Cell fusion is a standard lab technique for creating hybrid cells.
Existing methods have limitations in efficiency and control.

Purpose of the Study:

To develop a microfluidics-based method for controlled cell pairing and high-efficiency fusion.
To improve upon existing cell fusion techniques.

Main Methods:

Utilized a microfluidic device with passive hydrodynamics and weir-based traps for cell immobilization and pairing.
Employed chemical or electrical protocols for cell fusion post-pairing.

Main Results:

Achieved controllable formation of thousands of cell pairs.
Demonstrated a two- to tenfold improvement in fusion yields compared to commercial systems.

Conclusions:

The microfluidic approach offers a significant advancement in cell fusion technology.
Enables efficient generation of hybrid cells for various research applications.