Suppression of humoral immune responses in mice by antigens derived from Trichomonas vaginalis

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D Chao1, S R Wong, H T Ng

  • 1Department of Biology, National Sun Yat-sen University, Kaohsiung, Republic of China.

Proceedings of the National Science Council, Republic of China. Part B, Life Sciences
|July 1, 1989
PubMed

The occurrence of immunosuppression in mice inoculated with antigens prepared from Trichomonas vaginalis was investigated in this study. One hundred and fourteen BALB/c mice with half of each sex were divided into 19 groups and inoculated with different antigen preparations before or after sheep red blood cell (Srbc) immunization. Antigen preparations included live T. vaginalis (LTV), excretory and secretory products (ESP), and freeze and thaw antigens (FTA). The immunosuppressive effects of these T. vaginalis-derived antigens were demonstrated by the decrease of hemagglutination titers to Srbc. Results indicated that all three antigen preparations exhibited immunodepressive potentials in the primary and secondary responses to Srbc. Among them, FTA showed the highest inhibitory effect. The duration of the effect persisted for 21 days. The immunosuppressive effect was not observed for antigens which were given after Srbc injection.

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