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Effects of duration of breastfeeding during infancy on vascular dysfunction in adolescents

Sukman Tulus Putra1, Muchtaruddin Mansyur, Sudigdo Sastroasmoro

  • 1Department of Pediatrics and Child Helath, Faculty of Medicine Universitas Indonesia - Cipto Mangunkusumo Hospital, Jakarta, Indonesia.

Acta Medica Indonesiana
|May 8, 2015
PubMed

Insights

Breastfeeding for 4-6 months is linked to reduced carotid intima-media thickness (CIMT) in adolescents, suggesting a protective effect against cardiovascular disease. The impact on flow-mediated dilation (FMD) was not significant.

Area of Science:

  • Pediatrics
  • Cardiovascular Health
  • Public Health

Background:

  • Early life factors significantly influence long-term cardiovascular health.
  • Understanding the impact of breastfeeding duration on adolescent vascular development is crucial for preventative strategies.

Purpose of the Study:

  • To examine the association between breastfeeding duration and vascular characteristics in adolescents.
  • To determine if specific breastfeeding durations offer protective effects against early cardiovascular disease markers.

Main Methods:

  • Retrospective cohort study involving 285 adolescents aged 15-18 years.
  • Breastfeeding duration categorized (0-<2, 2-<4, 4-<6, 6-<12, >12 months) via parental questionnaires.
  • Vascular outcomes (flow-mediated dilation, carotid intima-media thickness) and anthropometrics assessed; analyzed using linear regression and MANOVA.

Main Results:

  • A breastfeeding duration of 4-6 months was associated with significantly thinner carotid intima-media thickness (CIMT).
  • This association remained significant after adjusting for gender and postnatal tobacco exposure (mean difference=24.28 µm, p=0.045).
  • No statistically significant association was observed between breastfeeding duration and flow-mediated dilation (FMD).

Conclusions:

  • Breastfeeding for 4-6 months demonstrates a protective effect on carotid intima-media thickness in adolescence.
  • This duration may play a role in mitigating the development of cardiovascular disease.
  • The relationship between breastfeeding duration and adolescent flow-mediated dilation requires further investigation.
Abstract

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