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Glyphosate poisoning with acute pulmonary edema.
Darshana Sudip Thakur1, Rajashree Khot1, P P Joshi1
1Department of Medicine, Indira Gandhi Government Medical College, Nagpur, Maharashtra, India.
Toxicology International
|May 8, 2015
Summary
Glyphosate-surfactant (GlySH) herbicide poisoning can cause severe systemic toxicity, including rare acute pulmonary edema. Early identification of prognostic factors and aggressive supportive care are crucial for survival in severe GlySH cases.
Area of Science:
- Toxicology
- Environmental Health
Background:
- Glyphosate-surfactant (GlySH) herbicide is widely used globally and generally considered low toxicity.
- However, severe systemic poisoning cases occasionally occur, challenging this perception.
Observation:
- Clinical manifestations of severe GlySH poisoning include gastroenteritis, respiratory distress, altered mental status, refractory hypotension, renal failure, and shock.
- Mortality is linked to pulmonary and renal toxicity, with metabolic acidosis, abnormal chest X-rays, arrhythmias, and elevated creatinine as prognostic indicators.
Findings:
- This case report details a rare instance of acute pulmonary edema following oral GlySH poisoning.
- The patient survived due to aggressive supportive therapy, highlighting its importance in managing severe GlySH intoxication.
Implications:
- Severe GlySH poisoning requires prompt recognition and intensive supportive management, as no specific antidote exists.
- Understanding prognostic factors can aid in risk stratification and treatment decisions for patients with GlySH exposure.
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