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Related Experiment Videos

Finding small molecules for the 'next Ebola'.

Sean Ekins1, Christopher Southan2, Megan Coffee3

  • 1Collaborations in Chemistry, 5616 Hilltop Needmore Road, Fuquay-Varina, NC, 27526, USA ; Collaborative Drug Discovery, 1633 Bayshore Highway, Suite 342, Burlingame, CA, 94010, USA.

F1000Research
|August 1, 2015
PubMed
Summary
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Preparing for future pathogen outbreaks requires strategic improvements in small molecule therapeutic development. Key steps include literature text mining, open patent declarations, and commoditizing reagents for faster response.

Area of Science:

  • Infectious Diseases
  • Drug Discovery
  • Public Health Preparedness

Background:

  • The recent Ebola virus epidemic highlights the need for improved strategies to combat future pathogen outbreaks.
  • Current approaches to discovering and utilizing small molecule therapeutics can be enhanced.

Purpose of the Study:

  • To propose cost-effective strategies for improving the discovery and use of small molecule therapeutics.
  • To outline actionable steps for better preparedness against future infectious disease threats.

Main Methods:

  • Literature text mining to identify relevant research and therapeutic targets.
  • Encouraging open declaration of patent filings by assignees and inventors.
  • Commoditizing reagents and assays for wider accessibility.
Keywords:
box modeldatabasesebolaopen scienceoutbreakpatentstext mining

Related Experiment Videos

  • Manual curation to improve database links and data accessibility.
  • Engaging with database and curation teams for enhanced data management.
  • Adopting open science approaches to facilitate collaboration and data sharing.
  • Adapting the "box" model for shareable reference compounds.
  • Incorporating the physician's perspective into the therapeutic development process.

    • Main Results:

    • Implementation of proposed strategies can lead to more efficient and effective small molecule therapeutic development.
    • Enhanced preparedness can mitigate the impact of future pathogen outbreaks.
    • Open science and data sharing accelerate the discovery and deployment of medical countermeasures.

    Conclusions:

    • A multi-faceted approach integrating technological, collaborative, and clinical perspectives is crucial for future pandemic preparedness.
    • Cost-effective measures can significantly impact the speed and success of small molecule therapeutic development.
    • Proactive strategies are essential to ensure a robust response to emerging infectious diseases.