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Non-V delta 2 gamma delta T lymphocytes as effectors of cancer immunotherapy
Jonathan Fisher1, Anne-Marijn Kramer2, Kenth Gustafsson2
1Section of Cancer; UCL Institute of Child Health ; London, UK.
Abstract:
Gamma delta T cells (γδT) are potent mediators of antitumor cytotoxicity and have shown promising efficacy in early phase clinical trials. Most is known about the tumoricidal properties of cells bearing the Vδ2 T cell receptor chain, but recent studies have demonstrated that cells with the Vδ1 chain and those with neither Vδ1 nor Vδ2 chains have properties which may make them more attractive anticancer effectors in adoptive immunotherapy.
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