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Experimental Melanoma Immunotherapy Model Using Tumor Vaccination with a Hematopoietic Cytokine
Published on: February 24, 2023
Targeting tumor-associated myeloid cells for cancer immunotherapy
Hong Qin1, Guowei Wei1, Dongho Gwak1
1Department of Lymphoma and Myeloma; The University of Texas MD Anderson Cancer Center ; Houston, TX, USA ; Center for Cancer Immunology Research; The University of Texas MD Anderson Cancer Center ; Houston, TX, USA.
Abstract:
Tumor-associated myeloid cells undermine the therapeutic efficacy of cancer immunotherapy by their inhibitory properties on immune effector cells. Development of therapeutic agents to deplete suppressive myeloid cells in tumor microenvironment requires identification of cell-specific targets. A competitive phage display technique on live cells paves the way to discovery of such a target.
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