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Related Experiment Video

Updated: Apr 12, 2026

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies

Published on: February 6, 2019

Author's view: radiation and immunotherapy as systemic therapy for solid tumors.

Steven N Seyedin¹, Chad Tang¹, James W Welsh¹

¹Department of Radiation Oncology; The University of Texas MD Anderson Cancer Center; Houston, TX USA.

|May 8, 2015

Summary

Tumors evade immune detection through immunosuppression, leading to immune checkpoint inhibitor development. Combining these inhibitors with radiation may induce systemic antitumor effects, according to preclinical and clinical findings.

Keywords:

CTLA4 PD1 PDL1 abscopal effect antibodies immune checkpoint inhibitors radiation therapy

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Area of Science:

Immunology
Oncology
Radiotherapy

Background:

Tumors can evade the immune system by creating an immunosuppressive environment.
Immune checkpoint inhibitors (ICIs) have been developed to counteract tumor-induced immunosuppression.
The abscopal effect, a systemic antitumor response, is a potential outcome of cancer therapies.

Purpose of the Study:

To review preclinical and clinical evidence on combining immune checkpoint inhibitors with radiation therapy.
To explore the potential for radiation and ICIs to induce abscopal (systemic) antitumor effects.

Main Methods:

Review of preclinical studies investigating combined ICI and radiation therapy.
Analysis of clinical trials evaluating the efficacy of combined ICI and radiation therapy.
Synthesis of data on abscopal effects observed in response to combined treatment.

Main Results:

Preclinical data suggest that combining ICIs with radiation can enhance systemic antitumor immunity.
Clinical investigations show promising results for combined ICI and radiation therapy in various cancers.
Observed abscopal effects indicate that local radiation can trigger distant tumor regression.

Conclusions:

Combining immune checkpoint inhibitors with radiation therapy is a promising strategy for cancer treatment.
The abscopal effect represents a significant potential benefit of this combined therapeutic approach.
Further research is warranted to optimize treatment protocols and expand patient eligibility for combined ICI and radiation therapy.