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Pathogenesis of glomerular haematuria

Claudia Yuste1, Eduardo Gutierrez1, Angel Manuel Sevillano1

  • 1Claudia Yuste, Department of Nephrology, Gregorio Marañon Hospital, 28007 Madrid, Spain.

World Journal of Nephrology
|May 8, 2015
PubMed

Haematuria was known as a benign hallmark of some glomerular diseases, but over the last decade, new evidences pointed its negative implications on kidney disease progression. Cytotoxic effects of oxidative stress induced by hemoglobin, heme, or iron released from red blood cells may account for the tubular injury observed in human biopsy specimens. However, the precise mechanisms responsible for haematuria remain unclear. The presence of red blood cells (RBCs) with irregular contours and shape in the urine indicates RBCs egression from the glomerular capillary into the urinary space. Therefore glomerular haematuria may be a marker of glomerular filtration barrier dysfunction or damage. In this review we describe some key issues regarding epidemiology and pathogenesis of haematuric diseases as well as their renal morphological findings.

Keywords:
Chronic kidney diseaseDysmorphic red blood cellsGlomerular filtration barrierHaematuriaMicroscopic haematuriaPathogenesis

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