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Updated: Apr 12, 2026

Hyperpolarized 13C Metabolic Magnetic Resonance Spectroscopy and Imaging

Hyperpolarized 13C Metabolic Magnetic Resonance Spectroscopy and Imaging

Published on: December 30, 2016

Imaging metabolism with hyperpolarized (13)C-labeled cell substrates.

Kevin M Brindle^1,2

¹Department of Biochemistry, University of Cambridge, Tennis Court Road, Cambridge CB2 1GA, U.K.

Journal of the American Chemical Society

|May 8, 2015

Summary

Dynamic nuclear polarization enhances magnetic resonance spectroscopy for in vivo metabolic studies. This technique offers improved sensitivity and resolution, paving the way for clinical applications in diseases like prostate cancer.

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Area of Science:

Metabolic research
Magnetic resonance imaging
Biochemistry

Background:

Non-invasive (13)C magnetic resonance spectroscopy (MRS) studies metabolic fluxes in vivo.
Limited sensitivity of conventional MRS restricts spatial and temporal resolution.

Purpose of the Study:

To review the advancements and clinical potential of dissolution dynamic nuclear polarization (DNP) enhanced (13)C-MRS.
To discuss substrates, kinetic data analysis, and future improvements for DNP-MRS.

Main Methods:

Dissolution dynamic nuclear polarization (DNP) enhances (13)C nuclear spin polarization by over 10^4-fold.
Achieves second-level temporal and millimeter-level spatial resolution for in vivo metabolic studies.

Main Results:

DNP-enhanced (13)C-MRS significantly improves sensitivity, overcoming previous limitations.
Pre-clinical studies demonstrate potential for novel insights into tissue metabolism.
The technique is progressing towards clinical translation, with initial trials in prostate cancer.

Conclusions:

DNP-enhanced (13)C-MRS is a revolutionary tool for studying metabolism in vivo.
The method shows promise for broader clinical applications and further optimization is ongoing.