Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

The Retinoblastoma Gene01:20

The Retinoblastoma Gene

5.0K
Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
The first-ever tumor suppressor gene called Rb was identified in retinoblastoma - a rare eye tumor in children. In inherited forms of the disease, a child inherits one defective copy of the Rb gene, which predisposes them to retinoblastoma. However,...
5.0K
Negative Regulator Molecules01:23

Negative Regulator Molecules

39.1K
Positive regulators allow a cell to advance through cell cycle checkpoints. Negative regulators have an equally important role as they terminate a cell’s progression through the cell cycle—or pause it—until the cell meets specific criteria.
39.1K
Cancer-Critical Genes II: Tumor Suppressor Genes01:05

Cancer-Critical Genes II: Tumor Suppressor Genes

10.2K
Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
10.2K
Abnormal Proliferation02:23

Abnormal Proliferation

5.4K
Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
5.4K
Tumor Progression02:07

Tumor Progression

8.0K
Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
8.0K
Inhibition of Cdk Activity02:34

Inhibition of Cdk Activity

6.2K
The orderly progression of the cell cycle depends on the activation of Cdk protein by binding to its cyclin partner. However, the cell cycle must be restricted when undergoing abnormal changes. Most cancers correlate to the deregulated cell cycle, and since Cdks are a central component of the cell cycle, Cdk inhibitors are extensively studied to develop anticancer agents. For instance, cyclin D associates with several Cdks, such as Cdk 4/6, to form an active complex. The cyclin D-Cdk4/6 complex...
6.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Harrison and Chan Reply.

Physical review letters·2023
Same author

Magic Gap Ratio for Optimally Robust Fermionic Condensation and Its Implications for High-T_{c} Superconductivity.

Physical review letters·2022
Same author

Prior differences in previous trauma exposure primarily drive the observed racial/ethnic differences in posttrauma depression and anxiety following a recent trauma.

Psychological medicine·2022
Same author

Accuracy of selected neurological clinical tests in diagnosing MRI-detectable forebrain lesion in dogs.

Australian veterinary journal·2020
Same author

Incidence, cause, outcome and possible risk factors associated with facial nerve paralysis in dogs in a Sydney population (2001-2016): a retrospective study.

Australian veterinary journal·2019
Same author

Correlation between scale-invariant normal-state resistivity and superconductivity in an electron-doped cuprate.

Science advances·2019

Related Experiment Video

Updated: Apr 12, 2026

RNAscope for In situ Detection of Transcriptionally Active Human Papillomavirus in Head and Neck Squamous Cell Carcinoma
10:26

RNAscope for In situ Detection of Transcriptionally Active Human Papillomavirus in Head and Neck Squamous Cell Carcinoma

Published on: March 11, 2014

28.4K

Expression of p16INK4 and Rb Genes in Cervical Neoplasm.

Y F Wong1, T H Cheung, T K Chung

  • 1*Department of Obstetrics and Gynaecology †Department of Anatomical and Cellular Pathology, The Chinese University of Hong Kong, Shatin, N.T., Hong Kong.

Journal of Lower Genital Tract Disease
|May 8, 2015
PubMed
Summary

Tumor suppressor gene p16 and Rb protein alterations are involved in cervical cancer development. Their deficiencies contribute to oncogenesis in different patient subgroups, with distinct roles in premalignant and malignant cervical neoplasm.

More Related Videos

Chromogenic In Situ Hybridization as a Tool for HPV-Related Head and Neck Cancer Diagnosis
06:57

Chromogenic In Situ Hybridization as a Tool for HPV-Related Head and Neck Cancer Diagnosis

Published on: June 14, 2019

11.5K
Analysis of Cell Cycle Position in Mammalian Cells
12:19

Analysis of Cell Cycle Position in Mammalian Cells

Published on: January 21, 2012

61.7K

Related Experiment Videos

Last Updated: Apr 12, 2026

RNAscope for In situ Detection of Transcriptionally Active Human Papillomavirus in Head and Neck Squamous Cell Carcinoma
10:26

RNAscope for In situ Detection of Transcriptionally Active Human Papillomavirus in Head and Neck Squamous Cell Carcinoma

Published on: March 11, 2014

28.4K
Chromogenic In Situ Hybridization as a Tool for HPV-Related Head and Neck Cancer Diagnosis
06:57

Chromogenic In Situ Hybridization as a Tool for HPV-Related Head and Neck Cancer Diagnosis

Published on: June 14, 2019

11.5K
Analysis of Cell Cycle Position in Mammalian Cells
12:19

Analysis of Cell Cycle Position in Mammalian Cells

Published on: January 21, 2012

61.7K

Area of Science:

  • Oncology
  • Molecular Biology
  • Pathogenesis

Background:

  • Cervical cancer pathogenesis involves complex molecular events.
  • Understanding tumor suppressor gene roles is crucial for defining cervical neoplasm development.
  • p16 and Rb are investigated as key players in cervical cancer.

Purpose of the Study:

  • To investigate the expression patterns of p16 and Rb proteins in cervical intraepithelial neoplasia (CIN) and cervical cancer.
  • To determine the relationship between p16 and Rb expression in premalignant and malignant cervical lesions.

Main Methods:

  • Tissue samples from 16 CIN and 91 cervical cancer patients were analyzed.
  • Immunohistochemical staining was used to assess p16 and Rb protein expression.
  • Statistical analysis was performed to evaluate expression relationships and clinical correlations.

Main Results:

  • Negative p16 expression was significantly more prevalent in CIN (50%) than in cervical carcinoma (10%).
  • Negative Rb expression was observed in 25% of CIN and 37% of cervical carcinoma cases.
  • Alterations in p16 and Rb were largely exclusive and not significantly related to tumor type, grade, or stage.

Conclusions:

  • Deficiency in either p16 or Rb protein contributes to cervical oncogenesis in specific patient subgroups.
  • The role of negative p16 expression in CIN pathogenesis requires further confirmation.
  • Distinct expression patterns suggest differential involvement of p16 and Rb in cervical neoplasm progression.