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MicroRNAs

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After...

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Updated: Apr 12, 2026

Combination of Microstereolithography and Electrospinning to Produce Membranes Equipped with Niches for Corneal Regeneration

Combination of Microstereolithography and Electrospinning to Produce Membranes Equipped with Niches for Corneal Regeneration

Published on: September 12, 2014

MicroRNAs in skin tissue engineering.

Kyle J Miller¹, David A Brown¹, Mohamed M Ibrahim¹

¹Division of Plastic and Reconstructive Surgery, Department of Surgery, Duke University Medical Center, Durham, NC 27710, USA.

Advanced Drug Delivery Reviews

|May 9, 2015

Summary

This summary is machine-generated.

Skin tissue engineering faces challenges with current bioengineered skin equivalents (BSEs). MicroRNA offers a novel approach to enhance BSE design and address unmet clinical needs in treating major skin loss.

Keywords:

Bioengineering Dermis Epidermis RNAi miRNA

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Area of Science:

Biomedical Engineering
Regenerative Medicine
RNA Interference

Background:

Major skin loss affects 35.2 million Americans annually, driving demand for advanced treatments.
Skin tissue engineering has evolved over 40 years, traditionally using a cell-scaffold-signal approach.
Current bioengineered skin equivalents (BSEs) have limitations: long generation times, poor survival, and mass transfer issues.

Purpose of the Study:

To review advancements in skin tissue engineering.
To explore the potential of microRNA in overcoming current BSE limitations.
To identify microRNA targets for cellular processes, bioactive mediators, and scaffolds in skin tissue engineering.

Main Methods:

Review of existing literature on skin tissue engineering principles.
Analysis of the role of microRNA in regulating cellular behavior and tissue milieu.
Discussion of potential microRNA applications in enhancing BSEs.

Main Results:

MicroRNA (miRNA) technology presents a promising avenue to overcome existing challenges in BSE design.
miRNA can modulate cellular functions and the local tissue environment for improved skin regeneration.
Specific miRNA targets within cellular components, bioactive mediators, and scaffolds can be identified.

Conclusions:

MicroRNA-based strategies hold significant potential to enhance and expand the field of skin tissue engineering.
This approach offers a novel solution for the vast unmet clinical need in treating skin loss.
Future applications of microRNA in skin regeneration are promising and warrant further investigation.