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Spatiotemporal dynamics of the postnatal developing primate brain transcriptome.

Trygve E Bakken1, Jeremy A Miller1, Rui Luo2

  • 1Allen Institute for Brain Science, Seattle, WA, USA.

Human Molecular Genetics
|May 9, 2015
PubMed
Summary
This summary is machine-generated.

Gene expression in rhesus monkey brains changes most from birth to infancy, stabilizing by adulthood. A specific gene network linked to autism spectrum disorder (ASD) shows altered expression during early development.

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Area of Science:

  • Neuroscience
  • Genomics
  • Developmental Biology

Background:

  • Normal brain function relies on precise gene expression timing and location during development.
  • Disruptions in developmental gene regulation are implicated in neurodevelopmental disorders.

Purpose of the Study:

  • To map whole-genome gene expression profiles in rhesus monkey brains from birth to adulthood.
  • To understand primate brain development and identify gene expression patterns relevant to neurodevelopmental abnormalities.

Main Methods:

  • Whole-genome transcriptional profiling of rhesus monkey brains across developmental stages.
  • Biological pathway enrichment analysis.
  • Co-expression network analysis.

Main Results:

  • Gene expression dynamics are most pronounced from birth through infancy, stabilizing by young adulthood.
  • Genes highly expressed at birth are linked to cell adhesion and neuron differentiation; adult-expressed genes are associated with cell death.
  • The neocortex exhibits greater temporal gene expression changes than subcortical structures.
  • A specific co-expression module, enriched for autism spectrum disorder (ASD)-related genes, shows decreased expression from neonatal to juvenile stages and is linked to axon guidance and interneuron differentiation.

Conclusions:

  • Primate brain development involves significant shifts in gene expression, particularly in the neocortex.
  • A subset of developmental genes, when dysregulated, may contribute to the pathophysiology of autism spectrum disorder (ASD).
  • These findings provide a foundation for understanding primate brain development and neurodevelopmental disorders.