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Neuroinvasive cryptococcosis in an immunocompetent patient with a negative spinal fluid cryptococcus antigen
Rocio C Garcia-Santibanez1, Veenu Gill2, Stanley Yancovitz2
1Department of Neurology, Mount Sinai Beth Israel, New York, NY 10003, USA.
Abstract:
58-year-old man presented with headache, nausea, vomiting, and gait disturbance. Brain MRI showed meningeal enhancement and herniation. Serum Cryptococcus antigen was positive but spinal fluid antigen and cultures were negative. A cerebellar biopsy revealed nonencapsulated Cryptococcus. He completed antifungal therapy. Serum Cryptococcus antigen titer decreased. He had a full neurological recovery.
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