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[Hematologic changes in children small for gestational age].

S Ilić, V Grubacić

    Srpski Arhiv Za Celokupno Lekarstvo
    |May 1, 1989
    PubMed
    Summary
    This summary is machine-generated.

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    Children born small for gestational age exhibit significant hematologic and coagulation abnormalities, including polycythemia and prolonged clotting times. These changes were less pronounced in appropriately grown infants, highlighting risks for growth-restricted neonates.

    Area of Science:

    • Neonatal Medicine
    • Pediatric Hematology
    • Perinatology

    Context:

    • Investigated hematologic and coagulation status in neonates.
    • Compared infants small for gestational age (SGA) with those appropriate for gestational age (AGA).
    • Included 60 neonates with gestational ages between 31-39 weeks and birth weights of 950-2650 grams.

    Purpose:

    • To examine hematologic and coagulation changes in SGA neonates.
    • To compare these changes with those in AGA neonates.
    • To identify specific hematologic and coagulation alterations associated with intrauterine growth restriction.

    Summary:

    • SGA neonates (n=34) showed polycythemia, hyperviscosity, thrombocytopenia, reticulosis, and leucopenia.
    • Coagulation abnormalities in SGA infants included prolonged thrombin time, prothrombin time, and partial thromboplastin time.

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  • Decreased fibrinogen, elevated fibrin degradation products, reduced vitamin K-dependent factors, and lower antithrombin III were observed in SGA infants.
  • AGA neonates (n=26) exhibited significantly fewer hematologic and coagulation disturbances.

    • Impact:

    • Highlights the hematologic and coagulation risks in neonates with intrauterine growth restriction.
    • Provides data for understanding the pathophysiology of SGA-related complications.
    • Informs clinical monitoring and management strategies for high-risk neonates.