Clindamycin and ibuprofen effects on chlamydial salpingitis in mice

To evaluate the effects of clindamycin and ibuprofen on a model of upper genital tract chlamydial infection in mice, 64 Swiss Webster white mice were inoculated in the left ovarian bursa with a mouse pneumonitis strain of Chlamydia trachomatis. Chlamydia-inoculated mice received clindamycin, ibuprofen, clindamycin and ibuprofen, or no treatment. Mice were killed at intervals, and their genital tracts were examined grossly and microscopically for evidence of infection and cultured for Chlamydia. Sixty-seven per cent of inoculated, untreated mice manifested gross evidence of inflammation compared with 22.4% of mice in any treatment group (P less than .025). C. trachomatis was isolated in 10.2% of mice treated with any drug regimen, whereas 46.7% of untreated mice were culture-positive (P less than .025). In this model, therapy with clindamycin, ibuprofen, or both drugs in combination decreased gross and histologic evidence of inflammation as well as the rate of recovery of C. trachomatis from the genital tract.