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A fluorescent bisboronic acid compound that selectively labels cells expressing oligosaccharide Lewis X
Xingming Gao1, Mengyuan Zhu1, Haiying Fan2
1Department of Chemistry and Center for Diagnostics and Therapeutics, Georgia State University, Atlanta, GA 30303, USA.
Bioorganic & Medicinal Chemistry Letters
|May 10, 2015
Abstract:
Two fluorescent diboronic acid compounds (6a and 6b) with a dipeptide linker were synthesized as potential sensors for cell surface saccharide Lewis X (Le(X)). Compound 6a with a dipeptide (H-Asp-Ala-) as the linker was found to selectively label CHOFUT4 cells, which express Le(x), at micromolar concentrations, while non-Le(x)-expressing control cells were not labeled.
