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Updated: Apr 12, 2026

Two- and Three-Dimensional Live Cell Imaging of DNA Damage Response Proteins
Published on: September 28, 2012
CtIP: A DNA damage response protein at the intersection of DNA metabolism
Nodar Makharashvili1, Tanya T Paull1
1The Howard Hughes Medical Institute, The Department of Molecular Genetics and Microbiology, The Institute for Cellular and Molecular Biology, The University of Texas at Austin, Austin, TX 78712, USA.
Abstract:
The mammalian CtIP protein and its orthologs in other eukaryotes promote the resection of DNA double-strand breaks and are essential for meiotic recombination. Here we review the current literature supporting the role of CtIP in DNA end processing and the importance of CtIP endonuclease activity in DNA repair. We also examine the regulation of CtIP function by post-translational modifications, and its involvement in transcription- and replication-dependent functions through association with other protein complexes. The tumor suppressor function of CtIP likely is dependent on a combination of these roles in many aspects of DNA metabolism.
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