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Axial spondyloarthritis: the heart of the matter

Lianne S Gensler1

  • 1University of California San Francisco (UCSF), 400 Parnassus Ave, Box 0326, San Francisco, CA, 94143, USA, Lianne.gensler@ucsf.edu.

Clinical Rheumatology
|May 11, 2015
PubMed

Insights

Cardiovascular issues like heart disease and conduction defects are common in spondyloarthritis, particularly ankylosing spondylitis. Further research is needed to understand the full extent of heart problems in all axial spondyloarthritis patients.

Area of Science:

  • Rheumatology and Cardiology
  • Inflammatory diseases
  • Cardiovascular manifestations

Background:

  • Spondyloarthritis (SpA) is a group of inflammatory diseases.
  • Cardiovascular clinical manifestations are known in established ankylosing spondylitis (AS).
  • These include structural heart disease, conduction defects, and ischemic heart disease.

Purpose of the Study:

  • To define the prevalence of cardiovascular involvement in axial spondyloarthritis (axSpA).
  • To include patients with non-radiographic disease in the assessment.
  • To further elucidate the spectrum of cardiac manifestations in axSpA.

Main Methods:

  • Review of existing literature on cardiovascular involvement in SpA.
  • Analysis of clinical data from patients with axSpA.
  • Epidemiological assessment of cardiac comorbidities in axSpA cohorts.

Main Results:

  • Established ankylosing spondylitis (AS) shows various cardiovascular manifestations.
  • Known issues include structural heart disease, conduction abnormalities, and ischemic events.
  • Prevalence data for non-radiographic axSpA is limited.

Conclusions:

  • Cardiovascular disease is a significant concern in spondyloarthritis.
  • The full prevalence in axial spondyloarthritis, including non-radiographic forms, requires further investigation.
  • Comprehensive cardiovascular assessment is crucial for managing SpA patients.

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