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Association of MicroRNA-146a rs2910164 Gene Polymorphism with Metabolic Syndrome

E T Mehanna1, M H Ghattas2, N M Mesbah1

  • 1Department of Biochemistry, Faculty of Pharmacy, Suez Canal University, Ismailia, Egypt.

Folia Biologica
|May 11, 2015
PubMed

Insights

The miRNA-146a rs2910164 C allele is linked to higher metabolic syndrome risk in Egyptian women. This genetic variant is associated with increased obesity, blood pressure, and lipid levels, indicating a role in disease susceptibility.

Area of Science:

  • Genetics
  • Molecular Biology
  • Epidemiology

Background:

  • MicroRNA-146a (miRNA-146a) expression is crucial in human disease development.
  • The miRNA-146a rs2910164 polymorphism is a functional variant associated with various diseases.
  • Metabolic syndrome involves a cluster of risk factors like impaired glucose tolerance, obesity, and hypertension.

Purpose of the Study:

  • To investigate the association between the miRNA-146a rs2910164 polymorphism and metabolic syndrome in Egyptian women.
  • To determine the relationship between this genetic variant and the individual component traits of metabolic syndrome.

Main Methods:

  • Genotyping of miRNA-146a rs2910164 using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) with Hpy188I.
  • Comparison of allele and genotype frequencies between 100 metabolic syndrome patients and 100 healthy controls.
  • Assessment of metabolic syndrome components including BMI, waist circumference, blood pressure, glucose, lipids, and insulin resistance.

Main Results:

  • The rare C allele of miRNA-146a rs2910164 was significantly more frequent in metabolic syndrome patients (P = 0.013).
  • Carriers of GC and CC genotypes exhibited increased body mass index, waist circumference, triglycerides, total cholesterol, LDL, and blood pressure.
  • The GC genotype was linked to higher fasting glucose, insulin, and insulin resistance, while CC genotype was associated with lower HDL levels.

Conclusions:

  • The C allele of miRNA-146a rs2910164 is positively associated with metabolic syndrome susceptibility and its phenotypic traits in the Egyptian women studied.
  • This polymorphism may serve as a genetic marker for metabolic syndrome risk.

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