[Study of DHA algal oil compound preparation on improving memory in mice]

To investigate the effects of docosahexaenoic acid (DHA) algal oil compound preparation on improving memory in mice.

A total of 144 KM mice weighed 18 - 22 gram were classified into three groups randomized for the step - down test, passive avoidance test and water maze test respectively. For each test, we select 48 mice initially, then allocated the mice into 4 groups at random, each with 12 mice. According to the recommended dose of DHA algae oil soft capsule (600 mg/d) for human, each adult weight calculating on 60 kg meters, then we calibrate the dose to 50, 100 and 300 mg/kg BW (the equivalent doses of 5, 10 and 30 times to human) for three groups, respectively. The dose for intragastric injection administration is 10 ml/kg BW DHA algae oil, equivalent amount of edible vegetable oil for the control group, once per day for continuous 30 days. Just after the last lavage, we conduct the step - down test, passive avoidance test and water maze test respectively.

DHA algal oil compound preparation has obvious effect on improving the reappearance ability of passive avoidance and the response of the avoiding darkness (P < 0.05). The indicators of water maze test were different statistically between DHA algal oil compound preparation groups and control group (P < 0.05).

DHA algal oil compound preparation may play an important role in memory improvement in mice.