[Healing of experimental defect in a long bone after implantation of "CollapAn" osteoplastic material in its cavity...

The dynamics of biodegradation of "CollapAn" osteoplastic material was studied after its implantation into the defect of the femoral diaphysis in 30 rats. Computed tomographic analysis of the healing of bone defects was conducted with the determination of the optical density of bone tissue in Hounsfield units. Since Day 30 of the experiment, the appearance and further progress of the radiographic signs of bone tissue neoformation and maturation were noted exactly along the contours of osteoplastic material, together with the gradual disappearance of the defect from the side of bone cortical layer and simultaneous increase of the optical density of the intermediary and endosteal part of the regenerate. At Day 120, regenerate optical density exceeded the absolute optical density of the parent bone; simultaneously, during this period no full recovery of the original shape of the bone took place, while parent bone rarefication was identified during all the periods of observation.