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The relationship between the high-density lipoprotein (HDL)-associated sphingosine-1-phosphate (S1P) and coronary
Xiao-Dong Jing1, Xiao-Ming Wei1, Song-Bai Deng1
1Department of Cardiology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Insights
High-density lipoprotein (HDL)-associated sphingosine-1-phosphate (S1P) is a key predictor of coronary in-stent restenosis (ISR). Lower HDL-S1P levels indicate a higher risk of ISR, suggesting its potential as a biomarker.
Area of Science:
- Cardiovascular Science
- Biochemistry
- Medical Research
Background:
- High-density lipoprotein (HDL)-associated sphingosine-1-phosphate (S1P) has known cardiovascular benefits.
- The relationship between HDL-S1P concentrations and coronary in-stent restenosis (ISR) requires further investigation.
Purpose of the Study:
- To explore the association between HDL-S1P concentrations and the occurrence of ISR.
- To determine if HDL-S1P is an independent predictor of ISR.
Main Methods:
- Serum S1P and HDL-S1P levels were measured in 50 patients with ISR and 50 controls.
- Clinical data and ISR rates were analyzed in relation to HDL-S1P quartiles.
- Multivariate logistic regression and ROC analyses were performed.
Main Results:
- Patients with ISR had significantly lower serum S1P and HDL-S1P concentrations.
- ISR rates decreased progressively with increasing HDL-S1P quartiles (84% in Q1 to 28% in Q4).
- HDL-S1P was identified as an independent predictor of ISR (OR=0.846, P=0.001).
Conclusions:
- HDL-S1P is a significant independent predictor of coronary in-stent restenosis.
- Higher concentrations of HDL-S1P are associated with a reduced risk of ISR.
Background:
High-density lipoprotein (HDL)-associated sphingosine-1-phosphate (S1P) contributed to several beneficial effects in the cardiovascular system. We explored the relationship between the HDL-S1P concentrations and coronary in-stent restenosis (ISR).
Methods:
Fifty consecutive patients with ISR and 50 normal control subjects were included. The serum S1P, HDL-S1P and clinical data were collected to explore the relationships between these parameters and ISR.
Results:
The patients with ISR had significantly lower concentrations of serum S1P (96.10 ± 26.33 vs. 113.40 ± 32.72; P = 0.004) and HDL-S1P (32.81 ± 10.02 vs. 42.72 ± 11.75; P < 0.001). All included patients were divided into four quartiles based on their concentrations of HDL-S1P: Quartile 1 (18.63-28.51 ng/ml), Quartile 2 (28.62-37.28 ng/ml), Quartile 3 (37.35-45.27 ng/ml), and Quartile 4 (45.59-79.36 ng/ml). The rates of ISR were 84%, 48%, 40% and 28%, respectively. The patients in Quartile 1 exhibited significantly higher rates of ISR compared with the other groups (P = 0.001). A multivariate stepwise logistic regression analysis indicated that HDL-S1P (OR = 0.846, 95% CI = 0.767-0.932, P = 0.001) was an independent predictor of ISR. An ROC analysis indicated that HDL-S1P = 30.37 ng/ml and had a 90% sensitivity and a 52% specificity in predicting ISR.
Conclusions:
HDL-S1P is an independent predictor of ISR, and patients with higher concentrations of HDL-S1P have a low risk of ISR.
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