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Updated: Apr 12, 2026

Author Spotlight: Advancing Antibiotic Resistance Research Using an Efflux-Deficient Bacterial Strain and a Single-Copy Gene Expression System
Published on: January 5, 2024
Studies on tridecaptin B(1), a lipopeptide with activity against multidrug resistant Gram-negative bacteria
Stephen A Cochrane1, Christopher T Lohans, Marco J van Belkum
1Department of Chemistry, University of Alberta, 11227 Saskatchewan Drive, Edmonton, Alberta T6E 2M9, Canada. john.vederas@ualberta.ca.
Abstract:
Previously other groups had reported that Paenibacillus polymyxa NRRL B-30507 produces SRCAM 37, a type IIA bacteriocin with antimicrobial activity against Campylobacter jejuni. Genome sequencing and isolation of antimicrobial compounds from this P. polymyxa strain show that the antimicrobial activity is due to polymyxins and tridecaptin B1. The complete structural assignment, synthesis, and antimicrobial profile of tridecaptin B1 is reported, as well as the putative gene cluster responsible for its biosynthesis. This peptide displays strong activity against multidrug resistant Gram-negative bacteria, a finding that is timely to the current problem of antibiotic resistance.
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