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Cardiomyopathy With Frequent Ventricular Premature Depolarization – Predicting Irreversible Ventricular Dysfunction

Kyoung-Min Park1, Jihye Kim, Hayoung Na

  • 1Division of Cardiology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine.

Circulation Journal : Official Journal of the Japanese Circulation Society
|May 12, 2015
PubMed

Insights

Frequent ventricular premature depolarization (VPD) can cause left ventricular (LV) dysfunction. Left ventricular end-diastolic dimension (LVEDD) greater than 66 mm before ablation predicts irreversible LV cardiomyopathy (CMP) after successful VPD suppression.

Area of Science:

  • Cardiology
  • Electrophysiology
  • Cardiomyopathy Research

Background:

  • High burden of ventricular premature depolarization (VPD) is linked to left ventricular (LV) dysfunction.
  • LV dysfunction typically resolves post-ablation, but some patients experience persistent dysfunction.
  • Identifying predictors of irreversible LV cardiomyopathy (CMP) is crucial for patient outcomes.

Purpose of the Study:

  • To identify factors predicting irreversible left ventricular (LV) cardiomyopathy (CMP) in patients with frequent ventricular premature depolarization (VPD).
  • To evaluate the role of left ventricular end-diastolic dimension (LVEDD) in predicting persistent LV dysfunction after successful VPD suppression.

Main Methods:

  • Retrospective analysis of 57 patients with frequent VPD (>10%/day) undergoing successful radiofrequency (RF) ablation.
  • Patients were categorized based on LV function normalization post-ablation using transthoracic echocardiography (TTE).
  • Comparison of clinical, electrocardiographic, and TTE parameters, focusing on LV dimensions (LVEDD, LVESD).

Main Results:

  • Significant differences in pre-ablation LVEDD and LV end-systolic dimension between groups with reversible and irreversible LV dysfunction.
  • Pre-suppression LVEDD ≤66 mm was observed in all patients with reversible CMP.
  • LVEDD >66 mm demonstrated high specificity (100%) and positive predictive value (100%) for irreversible CMP.

Conclusions:

  • Left ventricular end-diastolic dimension (LVEDD) is a significant predictor of irreversible left ventricular cardiomyopathy (LV CMP) in patients with frequent ventricular premature depolarization (VPD).
  • An LVEDD >66 mm effectively predicts irreversible CMP with high specificity after successful VPD suppression.
Abstract

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