The role of 14-3-3 proteins in gynecological tumors

Related Experiment Video

Updated: Apr 12, 2026

Author Spotlight: Unveiling the Role of TMOD3 in Platinum Resistance and Immune Infiltration in Ovarian Cancer
09:40

Author Spotlight: Unveiling the Role of TMOD3 in Platinum Resistance and Immune Infiltration in Ovarian Cancer

Published on: August 2, 2024

3.3K

Wenwen Zhang, Qi Shen, Miaomiao Chen

  • 1Department of Obstetrics and Gynecology, the Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, 325027, China, zjwzzxq@yeah.net.

Frontiers in Bioscience (Landmark Edition)
|May 12, 2015
PubMed

Insights

Cellular 14-3-3 proteins are crucial in cell regulation and cancer. This review explores their role in gynecological malignancies as diagnostic markers and therapeutic targets.

Area of Science:

  • Cellular biology
  • Oncology
  • Biochemistry

Background:

  • 14-3-3 proteins are highly conserved and regulate key physiological processes including metabolism, protein trafficking, signal transduction, apoptosis, and cell cycle.
  • Their involvement in regulating tumor suppressor genes and oncogenes suggests a significant role in human cancer.
  • The function of 14-3-3 proteins in gynecological tumors is debated, with some studies indicating they promote tumor growth while others suggest a tumor-suppressive role.

Purpose of the Study:

  • To review the potential of 14-3-3 proteins as novel biomarkers for screening and early diagnosis of gynecological malignancies.
  • To explore their utility in monitoring treatment effectiveness for these cancers.
  • To discuss their proposed use as prognostic factors and therapeutic targets in cancer treatment.

Main Methods:

  • Literature review of studies on 14-3-3 proteins in gynecological cancers.
  • Analysis of research investigating the dual role of 14-3-3 proteins in tumor promotion and suppression.
  • Synthesis of findings related to diagnostic and therapeutic applications.

Main Results:

  • 14-3-3 proteins are implicated in the regulation of pathways critical to cancer development.
  • Evidence suggests their potential as early diagnostic markers for gynecological malignancies.
  • Their role in treatment monitoring and as therapeutic targets is under investigation.

Conclusions:

  • 14-3-3 proteins represent promising novel markers for the screening and early detection of gynecological cancers.
  • They may serve as valuable indicators for monitoring treatment response.
  • Further research is warranted to fully elucidate their prognostic value and therapeutic potential in oncology.

More Related Videos

Heterotypic Three-dimensional In Vitro Modeling of Stromal-Epithelial Interactions During Ovarian Cancer Initiation and Progression12:42

Heterotypic Three-dimensional In Vitro Modeling of Stromal-Epithelial Interactions During Ovarian Cancer Initiation and Progression

Published on: August 28, 2012

15.8K
Obtaining Cancer Stem Cell Spheres from Gynecological and Breast Cancer Tumors07:01

Obtaining Cancer Stem Cell Spheres from Gynecological and Breast Cancer Tumors

Published on: March 1, 2020

10.9K

Related Concept Videos

Negative Regulator Molecules01:23

Negative Regulator Molecules

Positive regulators allow a cell to advance through cell cycle checkpoints. Negative regulators have an equally important role as they terminate a cell’s progression through the cell cycle—or pause it—until the cell meets specific criteria.
39.1K
Abnormal Proliferation02:23

Abnormal Proliferation

Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
5.4K
Mitogens and the Cell Cycle02:38

Mitogens and the Cell Cycle

Mitogens and their receptors play a crucial role in controlling the progression of the cell cycle. However, the loss of mitogenic control over cell division leads to tumor formation. Therefore, mitogens and mitogen receptors play an important role in cancer research. For instance, the epidermal growth factor (EGF) - a type of mitogen and its transmembrane receptor (EGFR), decides the fate of the cell's proliferation. When EGF binds to EGFR, a member of the ErbB family of tyrosine kinase...
8.5K
Cancer-Critical Genes I: Proto-oncogenes01:33

Cancer-Critical Genes I: Proto-oncogenes

Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
12.1K
Destabilization of Microtubules01:45

Destabilization of Microtubules

The destabilization of microtubules can occur during different stages of the microtubule lifecycle, such as nucleation or elongation. It can take place at either end of the microtubule or in the microtubule lattices as a whole. The lifespan of individual microtubules within a cell varies according to the cell type and stage of the cell cycle. During interphase, the lifespan of the microtubule is about 30 minutes, while during cell division, it is about 15 minutes. In axonal microtubules of...
3.9K
Small GTPases - Ras and Rho01:24

Small GTPases - Ras and Rho

Ras and Rho are small monomeric GTPases that act downstream of receptor tyrosine kinase (RTK) and regulate various cellular processes. These GTPases switch between active and inactive states by binding to guanine nucleotides.
Three regulatory proteins control their activity:
5.8K