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Related Experiment Video

Updated: Apr 12, 2026

In Vitro Aggregation Assays Using Hyperphosphorylated Tau Protein
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Tau and neurodegenerative disorders.

Yumiko Motoi, Naruhiko Sahara, Taiki Kambe

    Biomolecular Concepts
    |May 12, 2015
    PubMed
    Summary

    Tau protein alterations can cause neuronal degeneration, but the exact mechanisms and differences in tauopathies remain unclear. This review covers tauopathies from clinicopathology to biochemical changes and research models.

    Area of Science:

    • Neuroscience
    • Biochemistry
    • Genetics

    Background:

    • The precise mechanisms by which tau protein becomes toxic and induces neuronal degeneration are not fully understood.
    • It remains uncertain whether diverse tauopathies share common neurodegenerative pathways or exhibit unique differences.

    Purpose of the Study:

    • To provide a comprehensive overview of tauopathies, bridging basic research (bench) with clinical applications (bedside).
    • To discuss clinicopathological findings in both familial and sporadic tauopathies, highlighting their similarities and distinctions.

    Main Methods:

    • Review of clinicopathological findings in familial and sporadic tauopathies.
    • Analysis of biochemical alterations in tau, including phosphorylation, truncation, and acetylation.
    • Examination of tauopathy model mice for research insights.

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    Main Results:

    • Evidence suggests tau alterations directly contribute to neuronal degeneration.
    • Discussion of similarities and differences between familial and sporadic tauopathies.
    • Focus on both pathological and physiological roles of tau, particularly during development.

    Conclusions:

    • Tauopathies are complex neurodegenerative disorders with multifaceted biochemical changes.
    • Model mice are crucial for advancing research on neurofibrillary tangles, axonopathies, and synaptic alterations in tauopathies.
    • Further research is needed to elucidate tau's toxic mechanisms and develop effective therapies.