Related Experiment Video
Updated: Apr 12, 2026

11:24
Measuring DNA Damage and Repair in Mouse Splenocytes After Chronic In Vivo Exposure to Very Low Doses of Beta- and Gamma-Radiation
Published on: July 3, 2015
11.6K
[The radiosensitivity change after low-dose irradiation, possible mechanisms and regularities]
Radiatsionnaia Biologiia, Radioecologiia
|May 13, 2015
Summary
Adaptive response (AR) induction is complex, with numerous mechanisms and high variability, making it unpredictable. This review suggests AR induction may not be as universally applicable as previously assumed.
Area of Science:
- Biology
- Genetics
- Biochemistry
Context:
- Reviews existing literature and presents novel findings on adaptive response (AR).
- Focuses on the induction, formation, and mechanisms of AR.
- Examines the expansion and universality of AR across different biological systems.
Purpose:
- To analyze the induction and formation of adaptive response (AR).
- To investigate the mechanisms, expansion, and universality of AR.
- To evaluate the predictability and practical universality of AR induction.
Summary:
- Adaptive response (AR) induction involves complex, numerous, and variable mechanisms.
- The phenomenon's absence in some individuals and situational dependence contribute to unpredictability.
- Findings challenge the previously held assumption of AR induction's universal applicability.
Impact:
- Highlights the intricate and variable nature of adaptive responses.
- Suggests a re-evaluation of the universality of adaptive response induction in biological contexts.
- Provides a foundation for future research into the specific conditions and limitations of AR.
Related Concept Videos
Mutations
45.8K
Mutations are changes in the sequence of DNA. These changes can occur spontaneously or they can be induced by exposure to environmental factors. Mutations can be characterized in a number of different ways: whether and how they alter the amino acid sequence of the protein, whether they occur over a small or large area of DNA, and whether they occur in somatic cells or germline cells.
Chromosomal Alterations Are Large-Scale Mutations
While point mutations are changes in a single nucleotide in...
Chromosomal Alterations Are Large-Scale Mutations
While point mutations are changes in a single nucleotide in...
45.8K
Mutations
98.2K
Overview
98.2K
Biological Effects of Radiation
19.8K
All radioactive nuclides emit high-energy particles or electromagnetic waves. When this radiation encounters living cells, it can cause heating, break chemical bonds, or ionize molecules. The most serious biological damage results when these radioactive emissions fragment or ionize molecules. For example, α and β particles emitted from nuclear decay reactions possess much higher energies than ordinary chemical bond energies. When these particles strike and penetrate matter, they...
19.8K
Spontaneous and Induced Mutations
3.3K
Spontaneous mutations arise infrequently during DNA replication due to errors in the process. A key factor behind these errors is tautomeric shifts in nitrogenous bases, where bases transition from keto to enol forms or amino to imino forms. This shift can alter base-pairing rules, leading to mutations. Additionally, reactive oxygen species (ROS) arising from aerobic metabolism can damage DNA, resulting in depurination (loss of a purine base) or depyrimidination (loss of a pyrimidine base).
3.3K
Nucleotide Excision Repair
5.9K
DNA Distortion and Damage
Cells are regularly exposed to mutagens—factors in the environment that can damage DNA and generate mutations. UV radiation is one of the most common mutagens and is estimated to introduce a significant number of changes in DNA. These include bends or kinks in the structure, which can block DNA replication or transcription. If these errors are not fixed, the damage can cause mutations, which in turn can result in cancer or disease depending on which sequences are...
Cells are regularly exposed to mutagens—factors in the environment that can damage DNA and generate mutations. UV radiation is one of the most common mutagens and is estimated to introduce a significant number of changes in DNA. These include bends or kinks in the structure, which can block DNA replication or transcription. If these errors are not fixed, the damage can cause mutations, which in turn can result in cancer or disease depending on which sequences are...
5.9K
Nucleotide Excision Repair
42.7K
Overview
42.7K

