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Deubiquitinating enzymes as oncotargets

Urszula L McClurg1, Craig N Robson1

  • 1Solid Tumour Target Discovery Laboratory, Newcastle Cancer Centre, Northern Institute for Cancer Research, Medical School, Newcastle University, Newcastle upon Tyne, UK.

Oncotarget
|May 13, 2015
PubMed

Insights

Deubiquitinating enzymes (DUBs) are crucial for maintaining cellular balance by regulating epigenetic processes like gene expression and DNA repair. Dysregulation of DUBs contributes to cancer development, highlighting their therapeutic potential.

Area of Science:

  • Molecular Biology
  • Epigenetics
  • Oncology

Background:

  • Carcinogenesis is a complex process influenced by post-translational modifications.
  • Epigenetics, stable changes in gene expression without altering DNA sequence, is critical in cancer development.
  • Ubiquitination and deubiquitination are key post-translational modifications regulating cellular processes.

Purpose of the Study:

  • To review the role of deubiquitinating (DUB) enzymes in epigenetic regulation.
  • To explore the impact of DUBs on transcription factors, histone modifications, DNA repair, and cell cycle.
  • To discuss the implications of DUBs in tumorigenesis and their potential as cancer therapeutics.

Main Methods:

  • Literature review focusing on deubiquitinating enzymes and their epigenetic functions.
  • Analysis of the regulatory roles of DUBs in gene expression, DNA damage repair, and cell cycle control.
  • Discussion of the link between DUB dysregulation and cancer development, progression, and metastasis.

Main Results:

  • Deubiquitinating enzymes play significant roles in regulating transcription factors and histone modifications.
  • DUBs are involved in DNA damage repair pathways and cell cycle regulation, crucial for maintaining genomic stability.
  • Imbalances in ubiquitination/deubiquitination pathways are associated with cancer development and metastasis.

Conclusions:

  • Deubiquitinating enzymes are vital regulators of epigenetic processes implicated in cancer.
  • Understanding DUB functions offers insights into tumorigenesis mechanisms.
  • Targeting DUBs presents a promising therapeutic strategy for cancer treatment.
Keywords:
DUBsandrogen receptorcancerchromatindeubiquitinationepigeneticshistones

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