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Nanoparticles based on oleate alginate ester as curcumin delivery system.

Mazhar Ali Raja, Chenguang Liu1, Zhenhua Huang

  • 1College of Marine life Sciences, Ocean University Of China No.5 Yushan Road, Qingdao 266003 Shandong Province, P.R.China. liucg@ouc.edu.cn.

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Oleate alginate ester (OAE) nanoparticles were developed to improve curcumin's solubility and stability. These curcumin-loaded OAE nanoparticles (Cur-OAE Nps) show sustained release and effective delivery to cancer cells.

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Area of Science:

  • Biomaterials Science
  • Nanotechnology
  • Drug Delivery

Background:

  • Curcumin exhibits poor aqueous solubility and stability, limiting its therapeutic applications.
  • Alginate, a natural polysaccharide, can be modified to enhance its properties for drug delivery.
  • Developing effective nanocarriers is crucial for improving curcumin's bioavailability and efficacy.

Purpose of the Study:

  • To synthesize and characterize a hydrophobic alginate derivative, oleate alginate ester (OAE).
  • To develop curcumin-loaded OAE nanoparticles (Cur-OAE Nps) for enhanced curcumin delivery.
  • To evaluate the physicochemical properties, in vitro release, and cellular effects of Cur-OAE Nps.

Main Methods:

  • Hydrophobic modification of alginate using methyl oleate to form OAE.
  • Characterization of OAE using FTIR and (1)HNMR spectroscopy.
  • Preparation of Cur-OAE Nps via sonication and characterization of particle size, zeta potential, and encapsulation efficiency.
  • In vitro release studies, cytotoxicity assays against MCF-7 cells, and cell uptake studies.

Main Results:

  • OAE exhibited a low critical aggregation concentration, facilitating self-assembly into nanoparticles.
  • Cur-OAE Nps demonstrated a negative zeta potential (-55.4±0.91 mV) and an average size of approximately 200 nm.
  • Encapsulation significantly enhanced curcumin's aqueous solubility and stability, with sustained release over one week.
  • Cur-OAE Nps showed a time- and concentration-dependent cytotoxic effect and sustained cellular uptake in MCF-7 cells.

Conclusions:

  • The developed OAE nanoparticles effectively encapsulate curcumin, improving its solubility and stability.
  • Cur-OAE Nps exhibit sustained drug release and promising cytotoxic effects against cancer cells.
  • These OAE-based nanoparticles represent a viable strategy for enhanced curcumin delivery in cancer therapy.