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Published on: February 24, 2023
Tumor-expressed IL-17D recruits NK cells to reject tumors
Robert Saddawi-Konefka1, Timothy O'Sullivan2, Emilie T Gross1
1Department of Pathology; University of California ; San Diego, CA USA.
Abstract:
Antitumor immunity suppresses tumorigenesis, but we do not understand how transformed cells initiate those immune responses that are essential for effective tumor immunosurveillance. Using the 3-MCA fibrosarcoma model, we identified IL-17D as a tumor-expressed cytokine that recruits natural killer cells, leading to the polarization of M1 macrophages and tumor rejection.
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