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Toxic delirium in a patient taking amantadine and trimethoprim-sulfamethoxazole
K V Speeg1, J A Leighton, A L Maldonado
1Department of Medicine, University of Texas Health Science Center, San Antonio 78284.
The American Journal of the Medical Sciences
|December 1, 1989
Abstract:
Acute mental confusion occurred in a patient on a stable dose of amantadine after he was started on trimethoprim-sulfamethoxazole. Discontinuation of the drugs led to rapid improvement. Studies in a rat model of organic cation secretion demonstrate that both amantadine and trimethoprim, but not sulfamethoxazole, inhibit the renal secretion of the organic cation procainamide. This case may represent an amantadine-trimethoprim interaction.