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Association between the CYP11B2 gene -344T>C polymorphism and coronary artery disease: a meta-analysis

Y Liu1, H L Liu2, W Han1

  • 1Department of Cardiology, The General Hospital of the Chinese Armed Police Forces, Beijing, China.

Genetics and Molecular Research : GMR
|May 13, 2015
PubMed

Insights

The CYP11B2 gene -344T>C polymorphism may influence coronary artery disease (CAD) risk, particularly in Caucasian and Asian populations. This meta-analysis highlights ethnic differences in genetic susceptibility to CAD.

Area of Science:

  • Genetics
  • Cardiovascular Disease Epidemiology
  • Molecular Biology

Background:

  • The association between the CYP11B2 gene -344T>C polymorphism and coronary artery disease (CAD) risk remains controversial.
  • Previous studies have yielded conflicting results regarding this genetic association.

Purpose of the Study:

  • To conduct a meta-analysis to clarify the relationship between the CYP11B2 gene -344T>C polymorphism and CAD risk.
  • To investigate potential ethnic variations in the association between the polymorphism and CAD.

Main Methods:

  • A systematic literature search was performed on PubMed, EMBASE, and China National Knowledge Infrastructure databases for studies published before April 2014.
  • Meta-analysis was employed to combine data from five studies involving 3687 subjects.
  • Stratified analyses were conducted based on ethnicity.

Main Results:

  • No significant overall association between the CYP11B2 -344T>C polymorphism and CAD risk was found in the general population.
  • Significant associations were observed in stratified analyses: a protective effect in Caucasians (TT vs TC: OR = 0.80) and an increased risk in Asians (TT vs TC: OR = 1.25).
  • Results remained robust after excluding a study that deviated from Hardy-Weinberg equilibrium.

Conclusions:

  • The CYP11B2 gene -344T>C polymorphism may be associated with susceptibility to coronary artery disease (CAD).
  • Ethnic background plays a role in the relationship between this polymorphism and CAD risk, suggesting differential susceptibility in Caucasian and Asian populations.

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